• br STAR Methods br Acknowledgments We are

  2019-07-04

  

  STAR★Methods Acknowledgments We are grateful to Amaia Lujambio, James Fagin, and Ramon Parsons for providing cell lines and Evripidis Gavathiotis for critical reading of the manuscript. We would like to thank Saboor Hekmaty for providing expertise with RNA-seq analysis. P.I.P. would like to ac

• The indigenous populations living at high mountain

  2019-07-04

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human Pyoluteorin molecular to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopulmonary a

• It is noteworthy that little is known as to

  2019-07-04

  

  It is noteworthy that little is known as to the role of autophagy in regulation of eNOS phosphorylation and eNOS uncoupling. eNOS monomers, but not eNOS dimers could be degraded by ubiquitination [39], harbingering the existence of protein degradation pathways in modulation of eNOS turnover and acti

• Enolase is an example of a moonlighting protein that display

  2019-07-04

  

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation.

• Apart from the ET system s role

  2019-07-04

  

  Apart from the ET system\'s role in regulating blood vessel tone, it is also involved in a variety of cellular processes that are relevant to DR. For example, the ET receptors influence the survival of retinal ganglion 5-Iodotubercidin molecular (McGrady et al., 2017; Tonari et al., 2012), developm

• Abdominal aortic aneurysm AAA is considered a major health c

  2019-07-04

  

  Abdominal aortic aneurysm (AAA) is considered a major health concern and is associated with extremely high rates of mortality in case of aortic rupture. The main pathophysiologic mechanisms leading to aortic dilation include the degradation of the extracellular matrix (ECM) components, such as colla

• Although the amino acid sequences of CUL A

  2019-07-04

  

  Although the amino H-Lys(Ac)-OH.HCl structure sequences of CUL4A and CUL4B share 82% identity, the existing studies have shown that these two proteins do not have significant functional redundancy. Elevated expression of CUL4A has been observed in a variety of cancer cells, such as breast cancer,

• AMD is equally active against

  2019-07-04

  

  AMD3100 is equally active against a broad range of HIV-1 and HIV-2 strains, but not against simian immunodeficiency virus (SIV) strains in human PBMC (De Clercq et al., 1994). At this moment it is not clear what coreceptor SIV is using in human PBMC, but it does not seem to be CXCR-4 (Feng et al., 1

• Supported by the Austrian Science Fund FWF grant P

  2019-07-04

  

  Supported by the Austrian Science Fund FWF (grant P22521-B18 to A.H.) and the Austrian National Bank (grant 14263 to A.H.). K.J. was funded by the PhD Program DK-MOLIN (FWF-W1241). Acknowledgements Introduction Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), a more sev

• br Introduction To detect exposure to

  2019-07-04

  

  Introduction To detect exposure to and effects of neuroactive pesticides in aquatic organisms, one widely used biomarker is cholinesterase (ChE) activity, which, among other possible functions, catalyzes the hydrolysis of the neurotransmitter (+)-Catechin hydrate (ACh) in the cholinergic synapse

• Structure similarity searches were conducted using the

  2019-07-03

  

  Structure similarity searches were conducted using the standalone version of the DALI program with the query structures scanned against a local current version of the PDB that has all chains as separate entries (Holm and Sander, 1995). The structural hits for each query were collected, even if the D

• The majority of APC C subunits

  2019-07-03

  

  The majority of APC/C subunits form a giant scaffold, which was originally named the arc lamp, based on its shape when viewing APC/C from one side (Figure 1 and Box 1) [24]. The scaffold consists of two modules: the TPR lobe resembles the curved post and lamp, and the platform resembles the Batimast

• In principle in vitro techniques for assessing enzyme

  2019-07-03

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized all-trans Retinal structure lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected wit

• Since clinical studies mostly involved cases that used

  2019-07-03

  

  Since clinical studies mostly involved cases that used MPA, data from studies that examined other types of progestogens are very limited. While the WHI study examined the combination of conjugated equine estrogens plus MPA [1], the Million Women Study [2] that also demonstrated an increased risk of

• Ramos cell http www apexbt com media

  2019-07-03

  

  Ramos cells carry a non-functional p53 and constitutively express the transcription factor, NF-κB (Nazari et al., 2011, Zand et al., 2008). There is much evidence to support the conclusion that the interruption of NF-κB activation promotes apoptosis in several hematological malignancies (Fabre et al

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