• The patient was consented to treatment on clinical trial NCT

  2019-05-29

  

  The patient was consented to treatment on clinical trial NCT02527447 and received treatment with salvage chemotherapy of mitoxantrone 12mg/m2/day IV on days 1–3, etoposide 200mg/m2/day continuous IV infusion (CIV) on days 8–10, and cytarabine 500mg/m2/day CIV on days 1–3 and 8–10 (EMA). Infectious p

• The recently published global consensus

  2019-05-29

  

  The recently published global consensus recommendations on prevention and management of rickets advocate for the eradication of rickets and osteomalacia through implementation of national supplementation and food fortification programmes containing vitamin D, calcium, or both. On the basis of high-q

• MADIT trial enrolled adult patients with prior myocardial in

  2019-05-29

  

  MADIT trial enrolled 196 adult patients with prior myocardial infarction more than 3 weeks (Q wave or elevated cardiac enzyme), with non-sustained ventricular tachycardia (a run of 3–30 of ventricular ectopic beats with a rate more than 120 beats per minute), with left ventricular ejection fraction

• In patients with systolic heart failure and

  2019-05-29

  

  In patients with systolic heart failure and a wide QRS complex, cardiac resynchronisation therapy (CRT) using left ventricular (LV) pacing has been shown to enhance survival, reduce heart failure hospitalisation and enhance exercise capacity in patients with all cyclooxygenase inhibitors of heart f

• br Mega cohort studies Remote monitoring

  2019-05-29

  

  Mega-cohort studies Remote monitoring collects a wealth of data from large numbers of patients which are not subject to saturation or overwritten memory counters within any implantable device. These databases provide an opportunity to better understand system function, patient condition, and dise

• The CONNECT trial conducted by Crossley

  2019-05-29

  

  The CONNECT trial conducted by Crossley et al. [22] was also a multicenter, prospective, randomized evaluation of wireless RM, which included 1997 patients implanted with ICDs or CRT-Ds. They were randomly assigned to the remote or in-office groups and followed up for 15 months. The median time from

• Preclinical studies have shown that adipocytes

  2019-05-29

  

  Preclinical studies have shown that adipocytes and MSCs play an important role in migration and dissemination of cancer cyp450 inhibitors [55,56]. Concerning osteosarcoma, one publication has reported that human MSCs injected through the caudal vein of mice bearing Saos-2- induced an increase in tu

• br Genetic basis for atrial

  2019-05-29

  

  Genetic basis for atrial standstill Genetic basis of conduction block Genes involved in cardiac development and bradycardia Development of the CCS is a complex biological process with the potential to be wrought with problems. Several transcription factors, including homeodomain proteins an

• br Control of visceral leishmaniasis

  2019-05-28

  

  Control of visceral leishmaniasis requires access to low-cost, safe, and effective treatment. Amphotericin causes infusion-related fever, rigor, and nephrotoxicity, limiting its use. Ambisome—a liposomal amphotericin manufactured by Gilead—is better tolerated and is effective as a single dose. How

• Al ser verdad lo anterior no lo es menos

  2019-05-28

  

  Al ser verdad lo anterior, no lo es menos que la cultura asentada en tiempos coloniales, a diferencia de la que llegó en los primeros tiempos de la conquista, respondía a la relativa ignorancia del mundo clásico en España, sobre todo del griego. Fue el país donde más se leyeron sus autores en traduc

• br The study by Jesse Berman and colleagues

  2019-05-28

  

  The study by Jesse Berman and colleagues published in is the first to systematically analyse the risk of hospital admissions and mortality associated with drought periods in the USA. As the authors state, this is an understudied topic, but of great concern in the USA and globally as climate chang

• The electrocardiogram showed narrow QRS complex regular tach

  2019-05-28

  

  The electrocardiogram showed narrow QRS complex regular tachycardia, which was terminated by rapid injection of adenosine triphosphate. During the tachycardia, the P wave was not identifiable and was likely hidden completely in the QRS complex (Fig. 1). As the patient desired complete cure of the ta

• br Perioperative risk assessment of

  2019-05-28

  

  Perioperative risk assessment of thromboembolism The current thromboembolic risk stratification is largely based on indirect evidence from studies outside of the perioperative setting involving patients with a mechanical alkaline phosphatase inhibitor valve, chronic atrial fibrillation or venous

• br Introduction Sudden cardiac death SCD

  2019-05-28

  

  Introduction Sudden cardiac death (SCD) in patients with low ventricular function remains a substantial problem despite improved medical therapies [1–3]. Many patients require antiarrhythmic drugs to prevent recurrent arrhythmias and reduce the number of shocks from implanted cardioverter-defibri

• Early recognition of ICD lead malfunction

  2019-05-28

  

  Early recognition of ICD lead malfunction is desirable to prevent the life-threatening consequences of lead failure. Recent reports indicate that the majority of patients with ICD lead failure experience inappropriate ICD therapies, often as the presenting problem [4,6]. Regular device interrogation

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