• Early recognition of ICD lead malfunction is desirable to

  2019-06-19

  

  Early recognition of ICD lead malfunction is desirable to prevent the life-threatening consequences of lead failure. Recent reports indicate that the majority of patients with ICD lead failure experience inappropriate ICD therapies, often as the presenting problem [4,6]. Regular device interrogation

• All patients with symptomatic cardiac

  2019-06-19

  

  All 4 patients with symptomatic cardiac AL amyloidosis had poor prognoses. The median survival period for these 4 patients was 12.3 months (minimum=4 months, maximum=28 months) (Table 1). The patient in Case 2, whose BNP level was the highest of the 4 patients, had the shortest survival period. Howe

• Paying now rather than forever

  2019-06-18

  

  Paying now rather than forever has never been as relevant as a global health solution to the HIV pandemic than in 2013. The relative success of the ongoing replenishment session for the Global Fund is a positive signal, although still insufficient considering the evidence-based targets that are set

• La pregunta que fundamenta esta

  2019-06-18

  

  La pregunta que fundamenta esta investigación es acerca de la posibilidad de que los participantes de experiencias de acción colectiva urbana definan y re-definan sus pertenencias learn more la región y las naciones en las que se insertan. Este acercamiento a las representaciones que los sujetos con

• br Discussion A familial platelet disorder with a propensity

  2019-06-18

  

  Discussion A familial platelet disorder with a propensity to myeloid malignancy (FPD/MM) was first reported in 1978 and since then approximately 30 pedigrees with RUNX1 germline mutations have been reported in the literature [9,11]. The RUNX1 gene is composed of 10 exons (1–6, 7A, 7B, 7C and 8).

• A year old woman was referred to our

  2019-06-18

  

  A 77-year-old woman was referred to our medical center for second opinion for refractory CMML-2. She had been incidentally found to have mild leukocytosis, anemia, and thrombocytosis on routine laboratory analysis. At diagnosis her white blood cell count (WBC) was 12×10/L, hemoglobin was 10.8g/dL, a

• The recently published global consensus recommendations

  2019-06-18

  

  The recently published global consensus recommendations on prevention and management of rickets advocate for the eradication of rickets and osteomalacia through implementation of national supplementation and food fortification programmes containing vitamin D, calcium, or both. On the basis of high-q

• Dyslipidemia is characterized by increased total cholesterol

  2019-06-18

  

  Dyslipidemia is characterized by increased total cholesterol, LDL-C, and triglyceride levels, and decreased HDL-C levels. However, the association of ApoA1 polymorphism with serum HDL-C level remains controversial. The polymorphisms of ApoA1+84 TC, but not MspI, are associated with serum HDL-C. The

• IRF expression had previously been described

  2019-06-18

  

  IRF1 expression had previously been described as a factor that contributes to susceptibility for HIV-1 infection [14]. Our findings evidenced a different expression modulation of this transcription factor in the two groups of DC according with the expression of the important Th1 driving cytokine IL-

• br Practical use of the Sweet

  2019-06-18

  

  Practical use of the Sweet Tip™ screw-in lead Entrapment of screw-in lead Entrapment is a relatively rare complication that can occur with the Sweet Tip™ screw-in lead as often as with other types of leads [13,14]. In the Sweet Tip™ lead, the helix might become exposed in the atrium and the ri

• Cardiac fibroblasts express various ion channels in particul

  2019-06-18

  

  Cardiac fibroblasts express various ion channels, in particular voltage-gated K carboxypeptidase and nonselective cation channels of the transient receptor potential (TRP) family . Both K and TRP channels are important determinants of fibroblast function, with TRP channels acting as Ca entry pathwa

• In the past decade preclinical studies have addressed the pu

  2019-06-18

  

  In the past decade, preclinical studies have addressed the putative role of non-coding RNAs in tumorigenesis, metastasis and therapy response in osteotropic cancers. Besides long non-coding RNAs, microRNAs (miRs) represent a class of small non-coding RNAs, (18–25 nucleotides long), that regulate pro

• The majority of breast malignancies are hormone responsive a

  2019-06-18

  

  The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno

• corticotropin-releasing factor Introduction The heart beat p

  2019-06-18

  

  Introduction The heart beat provides the mechanical force for the pumping of oxygenated blood to, and deoxygenated blood away from, the peripheral tissues [1]. This depends critically on the orderly activation and recovery of electrical excitation through the myocardium. Disruptions of this can le

• Concurrent with the clinical evaluation of the family the

  2019-06-18

  

  Concurrent with the clinical evaluation of the family, the genetic findings from a molecular autopsy may help to elucidate the cause of death in the decedent, as well as provide a basis for cascade genetic testing of at-risk family members. Offering cascade genetic testing to asymptomatic relatives

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