• Another significant finding in our

  2020-01-02

  

  Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in PHA-767491 synthesis (Fig. 11). Because of the consistent protection conferred by CK2 inhibition duri

• c-di-AMP We postulate that OT contained in milk during

  2019-12-31

  

  We postulate that OT contained in milk during early postnatal development causes a mild enteroprotective preconditioning of the ER (Fig 9). This is perhaps akin to a mechanism shown by others [50], [51], [52], which is characterized by selective activation of the IRE1a/XBP1/eIF2a (via PKR) UPR pathw

• In contrast to SQLE HMGCR could be efficiently

  2019-12-31

  

  In contrast to SQLE, HMGCR could be efficiently degraded in Outcome lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our recently r

• Dysfunction of the ubiquitin proteasome system causes abnorm

  2019-12-31

  

  Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility [[7], [8], [9]]; this indicates that ubiquitination is essential for spermatogenesis and sperm function during fertilization. β-catenin i

• Present malarial chemotherapies mainly rely on a

  2019-12-31

  

  Present malarial chemotherapies mainly rely on a very few chemotypes or their allied structures such as quinolines, anti-folates and some cyclic endo-peroxides (Nayyar et al., 2012). Over the last few decades, the extensive and repetitive deployment of these drugs has stimulated resistance in the pa

• br Materials and methods br Acknowledgments br Introduction

  2019-12-31

  

  Materials and methods Acknowledgments Introduction Proton pumps convert the energy of high-energy compounds into the diltiazem hydrochloride sale of protons across biomembranes. They play two physiological roles: pH regulation and the formation of proton-motive forces in their membranes. T

• After repeated intermittent exposure to a

  2019-12-31

  

  After repeated, intermittent exposure to a psychostimulant an augmentation of drug response to motor activity is commonly observed, a phenomenon known as behavioral sensitization (Kalivas and Stewart, 1991, Steketee and Kalivas, 2011). On the other hand, several reports have pointed out that stress

• Following mutagenesis of the glucarpidase gene of Pseudomona

  2019-12-31

  

  Following mutagenesis of the glucarpidase gene of Pseudomonas sp. strain RS-16 [30], approximately 73% of the clones retained enzyme activity, as indicated by the clear zones and yellow precipitate surrounding their colonies. However, there were very few that had ‘halos’ around colonies that were da

• Errors are detected by comparing the output data against an

  2019-12-31

  

  Errors are detected by comparing the output data against an error free reference. After error detection, the process is restarted so that only one error is accounted. The susceptibility is inferred by the ratio between injected events and detected errors: = 100×errors÷events%. Error rates are obtai

• There are studies that evaluated the

  2019-12-31

  

  There are studies that evaluated the stability of CMV DNA over different periods of time. A study that evaluated stability of EDTA plasma samples stored over a 21-day period at 4 °C found no significant change in the viral loads or any trend of continued DNA degradation [9]. Another study did not fi

• Ligand independent activation of neuronal

  2019-12-31

  

  Ligand-independent activation of neuronal nuclear estrogen receptors may also continue to occur in absence of ovarian estrogens. AF-1 requires intracellular kinase cascade-dependent phosphorylation of specific residues in the A/B domain of nuclear estrogen receptors (Le Goff et al., 1994; Kato et al

• Research done thus far supports the hypothesis

  2019-12-31

  

  Research done thus far supports the hypothesis that MPA has detrimental effects on cognition, alone and in combination with estrogen; there are other FDA-approved progestogens that satisfy the uterus opposing effects that have not been cognitively profiled. An important goal to aid women\'s health i

• Introduction The first reference to a

  2019-12-30

  

  Introduction The first reference to a possible involvement of orexins in the effects of drugs of abuse appeared in 2003 and showed that orexigenic peptide neurons respond to the chronic administration of morphine followed by abrupt withdrawal symptoms caused by opioid receptor antagonists (Georgesc

• It is noteworthy that epidemiological studies have demonstra

  2019-12-30

  

  It is noteworthy that epidemiological studies have demonstrated that some GAD patients have experienced anxiety symptoms in childhood and young adulthood, whereas others have developed their disorder at a later age (especially persons ≥ 50 years of age) (Hoehn-Saric et al., 1993; Le Roux et al., 200

• p and p which are downstream of pAkt and

  2019-12-30

  

  p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and ixabepilone arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It is well known tha

15455 records 891/1031 page Previous Next First page 上5页 891892893894895 下5页 Last page