• Ten studies have examined the associations

  2020-08-03

  

  Ten studies have examined the associations of 5-HTTLPR and COMT Val158Met polymorphisms with alexithymia. Among them, five studies investigated the roles of 5-HTTLPR (Ham et al., 2005; Kano et al., 2012; Mandelli et al., 2013; Porcelli et al., 2015; Terock et al., 2018), and other five studies exami

• While Colwell P has been commonly used

  2020-08-03

  

  While Colwell P has been commonly used to determine plant-available P for many years, DGT P is developing into a promising technique which has been proven successful in fields fertilised with inorganic P (Mason et al., 2010), as well as more recently in pot experiments with OA (Six et al., 2014). W

• br Introduction The covalent attachment

  2020-08-03

  

  Introduction The covalent attachment of ubiquitin (Ub) to substrates plays a central role in regulating a broad range of biological processes in eukaryotes [1], [2]. Substrates can be modified with a single Ub (monoubiquitination) or with varying types of polyubiquitin chains (polyubiquitination)

• Introduction Double strand break DSB is the most deleterious

  2020-08-03

  

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs). Although environmental stress does not lead directly to DSB, it produces 4a 5 2 3.25 a damag

• We found that both DDR and DDR ECD

  2020-08-03

  

  We found that both DDR1 and DDR2 ECD increased matrix mineralization as compared to native cells, with the effect of DDR2 ECD being more prominent. Both soluble (DDR2/ECD) and membrane-bound DDR2 ECD (DDR2/-KD), when compared to wild-type cells, induced larger mineral deposits. In this regard, a rec

• Selected compounds were tested for stability in

  2020-07-31

  

  Selected compounds were tested for stability in human, rat and mouse liver microsomes (). All analogs inlcuding GSK4716 had short half-lives. Nonetheless, we have successfully replaced the acylhydrazone ruthenium red synthesis with a saturated amide and maintained potency and comparable metabolic s

• br Disclosure br Acknowledgments This study was partly suppo

  2020-07-31

  

  Disclosure Acknowledgments This study was partly supported by a Grant-in-Aid for Scientific Research B (22390391539) from JSPS, Japan. Introduction Taenia multiceps is a taeniid cestode with an adult stage that lives in the small intestine of dogs and other canids. The larval stage (Coenur

• Because sex steroids and growth hormone play

  2020-07-31

  

  Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these

• Calcitonin secreted by the thyroid and thymus glands can inh

  2020-07-31

  

  Calcitonin secreted by the thyroid and thymus glands can inhibit bone resorption through interaction with osteoclasts. In addition, calcitonin has been shown to delay the progress of early-stage osteoarthritis lesions induced by mechanical instability in a rabbit experimental model [34]. Human and s

• The chemical structure of curcusone D is different from

  2020-07-31

  

  The chemical structure of curcusone D is different from all of the reported DUB inhibitors. It contains cross-conjugated α, β-unsaturated ketones (Fig. 1A). A similar pharmacophore was previously described in the pan-DUB inhibitor prostaglandin lipid derivatives, which function as potent Michael rec

• br Associations between striatal D Rs and

  2020-07-31

  

  Associations between striatal D2Rs and disease Various disorders that are known to involve dysfunction of the dopamine system also exhibit D2R alterations in striatum. In some cases, D2R involvement has been inferred from the ability of D2R-based drugs to successfully treat disease symptoms or to

• br Common features of TdT pol and pol

  2020-07-31

  

  Common features of TdT, pol μ and pol λ TdT, pol μ and pol λ remain in a closed conformation throughout their catalytic cycle, contrary to pol β [24•, 53, 54•]. One possible explanation for this observation is that they have traded fidelity (which requires open-to-closed transition) for a very ti

• As part of a program to explore the key

  2020-07-31

  

  As part of a program to explore the key binding interactions between the core of 1 and DGAT-1 a systematic analysis of the aminopyrimidine subunit was initiated. A potential approach to improving passive permeability within this series would be to increase lipophilicity via incorporation of substitu

• Despite the important agronomic traits

  2020-07-30

  

  Despite the important agronomic traits regulated by SUMO, most research studies on SUMOylation have been mainly limited to model plants, such as Arabidopsis and rice (Wang et al., 2011), due to the lack of molecular tools specific to other economically relevant plants. On the other hand, plants harb

• Theileria equi and Babesia caballi are pear

  2020-07-30

  

  Theileria equi and Babesia caballi, are pear-shaped erythrocytic protozoan parasites that belong to the phenethyl Theileriidae and Babesidae, members of the phylum Apicomplexa (OIE, 2008). These two parasites cause acute haemolytic anemia in horses, mules, donkeys and zebras, known as equine piropla

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