• Many studies have documented that enolase acts as

  2021-02-02

  

  Many studies have documented that enolase acts as a plasminogen-binding protein and this interaction is involved in the tissue invasion and pathogenicity of the causative agents (Almeida et al., 2004; Avilan et al., 2000; Marcilla et al., 2007; Mundodi et al., 2008; Vanegas et al., 2007). Furthermor

• While PRRSV has been recently shown to

  2021-02-02

  

  While PRRSV has been recently shown to induce SGs, the exact nature of SG formation and its underlying mechanism of regulating antiviral immune response during PRRSV infection remain unclear (Zhou et al., 2017). Formation of PRRSV-induced SGs was observed in MARC145 SQ 22536 (Chen et al., 2018) and

• Mono and bi ubiquitination of two

  2021-02-02

  

  Mono- and bi-ubiquitination of two lysines, namely K70 and K76, in a small fraction of p33 replication co-factor has been demonstrated in yeast (Barajas and Nagy, 2010, Li et al., 2008). Because mutations of these lysines reduced TBSV repRNA replication in yeast and affected the ability of p33 to in

• In Senegal malaria remains a formidable public

  2021-02-02

  

  In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th

• Introduction Cytochrome P CYP A is the

  2021-02-01

  

  Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The Physostigmine hemisulfate level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response a

• Recently it was reported that Crm is linked to spindle

  2021-02-01

  

  Recently, it was reported that Crm1 is linked to spindle pole body (SPB) by Spc72 in 5,7-Dichlorokynurenic acid yeast [9]. Spc72 and Spc110 are two specific receptors of γ-tubulin complex (Tub4), which target Tub4 to SPB and mediate the nucleation of microtubules from SPB [20]. It was found that di

• Another breakthrough towards the understanding of the mechan

  2021-02-01

  

  Another breakthrough towards the understanding of the mechanisms responsible for stress-induced relapse to drug seeking behaviour is the evidence published by the group of Wise [34] in which they show that the activation of VTA CRF2 and not CRF1 receptors is responsible for stress-mediated relapse t

• Based on the ability of CRF to modulate

  2021-02-01

  

  Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur

• In this study we observed alterations in mRNA

  2021-02-01

  

  In this study, we observed alterations in mRNA levels of CRF receptors in the PFCx and Hip during the development of sensitization. In particular, in the Hip both CRF receptors showed significantly increased BRL 37344, sodium salt sale when the sensitization condition was established. Similarly, CR

• Sampling sediments is usually performed with grab

  2021-02-01

  

  Sampling sediments is usually performed with grab corers [16], [29]. The digested sludge analyzed by Ternes et al. [16] was taken directly from the digester and the activated sludge was obtained by Cyprodime hydrochloride of the slurry of STPs [16]. Collected samples are transported under cooled co

• In the current study cocaine did not significantly increase

  2021-02-01

  

  In the current study, cocaine did not significantly increase negative subjective effects and nepicastat did not increase these responses. This outcome is somewhat surprising given that the most commonly reported effect to date has been to increase the aversive properties of cocaine such as anxiety,

• br STAR Methods br Acknowledgments We thank

  2021-02-01

  

  STAR★Methods Acknowledgments We thank Geneviève Almouzni, Sophie Polo, Ralph Scully, Wael Mansour, and Jeremy Stark for providing cell lines and Wolf Heyer, Haico van Attikum, Martijn Luijsterburg, and Brendan Price for helpful discussions. We thank Ratna Weimer, Bettina Basso, Christel Braun,

• Diacylglycerol kinases DGK and are

  2021-02-01

  

  Diacylglycerol kinases (DGK) α and ζ are lipid kinases that limit diacylglycerol (DAG)-dependent activation pathways downstream of the TCR (Merida et al., 2015). Their upregulation in tumor infiltrating lymphocytes (TIL) has been linked to generation of hyporesponsive states that contribute to immun

• br Inhibition of DHODH The

  2021-02-01

  

  Inhibition of DHODH The final products 7a–n were assessed for their DHODH inhibitory activity on rat liver mitochondrial/microsomal membranes. A procedure adapted from the literature was employed (see Experimental), in which oxidation of DHO to ORO is monitored by following the concomitant reduct

• Cell lines which possess microglial or neuronal

  2021-02-01

  

  Cell lines which possess microglial or neuronal properties are uncomplicated and convenient in vitro models for studying Cy5 carboxylic acid (non-sulfonated) injury at the cellular and molecular levels. Microglial BV-2 cells are derived from the immortalized mouse microglia and exhibit many of the

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