• Our previous study had shown that silencing FFAR expression

  2021-09-17

  

  Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β BMS265246 mg [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may be involved in the anti

• br Introduction br Results br Discussion br Experimental br

  2021-09-17

  

  Introduction Results Discussion Experimental Acknowledgment Introduction Endocannabinoids, N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) have been found in most mammalian tissues and they stimulate cannabinoid CB1 and CB2 receptor activity thereby modulating se

• br Results and discussion Computer modelling studies suggest

  2021-09-17

  

  Results and discussion Computer modelling studies suggested that the endocyclic oxygens in furocoumarin derivatives, such as NSC 14613 3a (Fig. 1), could also coordinate metal ions in the HIV-1 IN enzyme active site and inhibit the integration of viral DNA. The coumarin moiety is found in variou

• It was revealed that various injured or

  2021-09-16

  

  It was revealed that various injured or infected organs of Hippeastrum produce a mixture of an orange-colored chalcone and flavans which can be oxidized to red-colored dimer (Wilmowicz et al., 2014, Wink and Lehmann, 1996), preventing the penetration of injured tissues by Phoma narcissi, Botrytis ci

• br Membrane Fusion Requires Rab GTPases Tethers and SNAREs

  2021-09-16

  

  Membrane Fusion Requires Rab-GTPases, Tethers, and SNAREs Regulation and Function of Rab5 Following endocytosis in metazoan cells, the Rab5-specific GEF Rabex5 binds to ubiquitinated cargo proteins, such as cell surface receptors or metabolite transporters, and subsequently activates Rab5 on e

• GR activity prevents GSSG overaccumulation by reducing this

  2021-09-16

  

  GR activity prevents GSSG overaccumulation by reducing this molecule to GSH (Kranner et al., 2006). High GR activity seems to be essential for undisturbed seed germination as GR and other enzymatic antioxidants maintain sunflower (Helianthus annuus L.) seeds vigour (Bailly et al., 2002). Germination

• Although resembling a differential symbiotic relationship

  2021-09-16

  

  Although resembling a differential symbiotic relationship, interplay between prostate tumour CAFs promotes PKM2/HIF-1-driven transcriptional regulation in prostate cancer cells that exploit lactate produced by CAFs and undergo epithelial-to-mesenchymal transition (EMT) [21]. Although recent observat

• We have previously established the pharmacokinetic

  2021-09-16

  

  We have previously established the pharmacokinetic profile and effective dose of MNF in the rat [43] and demonstrated the effectiveness of MNF as an anticancer drug in CCT241533 and xenograft models [44]. Moreover, MNF was found to effectively block GPR55 signaling in tumor cells [21]. The compound

• The importance of FXR FGF

  2021-09-16

  

  The importance of FXR-FGF15/19 signaling in BA homeostasis is illustrated by various BA malabsorption syndromes. Clinically, BA malabsorption causes diarrhea due to high BA concentrations in the colon that lead to secretion of water and electrolytes and stimulation of propulsive contractions [36]. P

• Taken together specific antibodies and SR SIM

  2021-09-16

  

  Taken together, specific cam kinase ii and SR-SIM used in the study helped uniquely visualize the distribution of lymphocytes and macrophages with their molecular expression in human cochleae. Using SR-SIM, we verified that resident IBA1-positive macrophages are widely distributed in human cochlea (

• The activation of the ERK pathway participates in the

  2021-09-16

  

  The activation of the ERK pathway participates in the transmission of pain signaling by sensitizing primary afferents (Ji et al., 2009, Lai et al., 2011). Thus, the blockade of ERK activation in the primary sensory LDE225 Diphosphate can reduce the mechanical hypersensitivity and the thermal hyperse

• br Discussion Agonist and antagonist action at the GluN GluN

  2021-09-16

  

  Discussion Agonist and antagonist action at the GluN1/GluN3 Thonzonium Bromide synthesis is known to be complex [4], [10]. Recombinant GluN1/GluN3 receptors produce only small excitatory currents in response to glycine, likely because of a combination of activation via GluN3 and desensitization

• The main results whose proofs

  2021-09-16

  

  The main results, whose proofs depend on the explicit calculation of , include To set our work into the historical context, we note that the transporter category algebras are skew group algebras, and thus are fully group-graded algebras. This work is partially motivated by the papers on fully group

• The ion conduction pathway reported herein accounts for

  2021-09-16

  

  The ion conduction pathway reported herein accounts for all known functional properties of EAAT/GltPh anion channels. Simulations reveal unitary current amplitudes and ion selectivities (Figures 3C and 3D) that resemble experimental results (Melzer et al., 2003, Wadiche and Kavanaugh, 1998). The cal

• Phylogenetic analysis of the secretin like hormones yields p

  2021-09-16

  

  Phylogenetic analysis of the secretin-like hormones yields poorly supported trees due to the short length of their peptide sequences (Dores et al., 1996). However, phylogenetic analyses typically show that the secretin-like peptides encoded by the proglucagon (glucagon, GLP-1 and GLP-2) and GIP Eze

15506 records 571/1034 page Previous Next First page 上5页 571572573574575 下5页 Last page