• A localization of GK to both a

  2022-08-24

  

  A localization of GK to both a cytoplasmic and perinuclear area of normal rat pancreatic beta-cells was reported in 1996 (Noma et al., 1996), which changed on acute hyperglycemia to a more diffuse staining throughout the cytoplasm. The localization of GK within the nucleus was first reported by Mura

• br Materials and methods br Results br Discussion

  2022-08-23

  

  Materials and methods Results Discussion Defective regulation and inappropriate activation of the HH signaling pathway is implicated in many cancers. SMO targeting inhibitors were the first to enter clinical trials, however complications with acquired resistance and toxicity, also exemplifi

• br Materials and methods br Results br

  2022-08-23

  

  Materials and methods Results Discussion Employment of GIPR signaling, specifically the direction of this manipulation, as a strategy to improve body weight remains a contentious subject of intense scientific investigation [22], [32], [33]. Despite the physiological benefits of GIP on 3-Met

• The ghrelin receptor is expressed

  2022-08-23

  

  The ghrelin receptor is expressed in a number of human malignancies including prostatic carcinoma cell lines [18,19] and tissues [20], breast carcinoma tumours and cell lines [21], testicular tumours [22], and malignant ovarian cysts and tumours [23]. In addition, it has an elevated level of express

• However T DM and associated hyperglycemia can

  2022-08-23

  

  However, T1DM and associated hyperglycemia can adversely affect the structure and function of the heart in several mechanisms including inhibiting the anabolic effect of insulin due to its deficiency, generation of higher levels of ROS and induction of lipid peroxidation, and subsequent activation o

• Additionally to their peripheral effects evidence indicate a

  2022-08-22

  

  Additionally to their peripheral effects, evidence indicate a role for ETs in the central nervous system (Mosqueda-Garcı́a et al., 1993). Indeed, using Northern blot analysis and in situ hybridization it has been shown the presence of immunoreactive ET of non-vascular origin and of neuronal location

• Most hexokinases are widely expressed

  2022-08-22

  

  Most hexokinases are widely expressed but distinct hexokinases predominate specific tissues (Katzen and Schimke, 1965, Rogers et al., 1975). Hexokinase I is found in all mammalian tissues, but is most abundant in the Pyridostatin and kidney (griffin et al., 1992). Hexokinase II is the primary hexoki

• br Statistical analysis The mean standard deviation

  2022-08-22

  

  Statistical analysis The mean, standard deviation, median, range, frequency, and percentage were used for data description. The chi-square (x2) test was used for analyses the differences in categorical variables in the 2-way table. Overall survival (OS) was defined as the time interval between t

• Some data also suggested that CCR could influence

  2022-08-22

  

  Some data also suggested that CCR5Δ32 could influence the progression of HCV-related liver diseases (Goulding et al., 2005; Hellier et al., 2003; Wald et al., 2004). However, after stratifying HCV+ individuals according to clinical/histological criteria, no association of CCR5Δ32 with these HCV-rela

• It is an open question if these in vitro

  2022-08-22

  

  It is an open question if these in vitro findings have implications for the use of sGC activators in the in vivo situation and in patients. Assuming that incorporation in de novo synthesised enzyme occurs during therapy, one might speculate that the duration of drug administration has an influence o

• br For some time it was known that membrane

  2022-08-22

  

  For some time, it was known that membrane-bound guanylate cyclases (GCs) of photoreceptor GYKI 52466 dihydrochloride in the retina respond to changes in the [Ca]. Lolley and Racz observed that synthesis of cyclic GMP (cGMP) was stimulated at only low [Ca], concluding that Ca has an inhibitory effe

• br Materials and methods br Results br Discussion The compou

  2022-08-22

  

  Materials and methods Results Discussion The compound P7C3 has been reported to activate NAMPT (Wang et al., 2014) and augment NAD+ levels, thereby promoting the survival of mature neurons and postnatal neurogenesis throughout the post-ischemic Plerixafor 8HCl (Loris et al., 2017). However

• H together with T also forms a binding

  2022-08-22

  

  H109, together with T112, also forms a binding site for H+ (Chen et al., 2004; Harvey et al., 1999). H+-binding at this site also inhibits GlyR-mediated currents. Notably, the vicinity of neurons experiences changes in pH, to a mild extent in physiological conditions such as when neurons fire (Chesl

• To maintain low Glu concentrations

  2022-08-22

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino Thiomyristoyl mg is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes,

• The rapid actions of glucocorticoids range from the producti

  2022-08-22

  

  The rapid actions of glucocorticoids range from the production of endocannabinoid as a retrograde messenger [9], to regulation of ion channels [10], [11], to inhibitory effects on immune STF 083010 [12], [13], [14]. Many different kinase signaling pathways have been implicated in the rapid actions

15642 records 381/1043 page Previous Next First page 上5页 381382383384385 下5页 Last page