• The current gold standard for diagnosing BAM or

  2022-09-01

  

  The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) GM 6001 (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated taurocholic acid and me

• Azidobutyric acid NHS ester ADAM has two alternative splicin

  2022-09-01

  

  ADAM12 has two alternative splicing forms, a membrane-anchored long form (ADAM12-L) and a secreted short form (ADAM12-S). Both the long and short forms have metalloproteinase, disintegrin, cysteine-rich, and epidermal growth factor-like domains and can shed pro-heparin binding-epidermal growth facto

• br Conclusion Discovery of an ideal orally

  2022-09-01

  

  Conclusion Discovery of an ideal orally active antithrombotic drug has remained elusive till date. Research efforts in this direction led to the discovery of numerous coagulation enzyme inhibitors including various thrombin and FXa inhibitors. Several preclinical studies have highlighted the impo

• br Introduction Thrombosis is one of the leading causes of

  2022-09-01

  

  Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable Palomid 529 australia and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism (VTE) afflicts about 1 m

• br Conclusions Symptoms from bilateral thalamic edema caused

  2022-09-01

  

  Conclusions Symptoms from bilateral thalamic edema caused by increased venous hypertension can be reversed with appropriate management of the inciting vascular lesion. This case demonstrates a rare patient with decreased CBF in the thalamus in SPECT and completely recovered after factor Xa inhibi

• br Conclusion In conclusion HER CTCs can be

  2022-08-31

  

  Conclusion In conclusion, HER2+ CTCs can be detected using the LiquidBiopsy system. Among the patients with histologically HER2+ breast cancer, 41.9% had ≥ 1 HER2+ CTC/4 mL of blood. The cell lines experiments showed high sensitivity (100%) and specificity (99.9%) using a HER2/CD45 fluorescence r

• br Other Functions of HCA Receptors HCA

  2022-08-31

  

  Other Functions of HCA Receptors HCA receptors, in particular HCA1, are expressed in various primary tumor sr1 77, 78, 79. This is of interest, as most solid tumors show increased glucose uptake and lactate formation even under normoxic conditions, with lactate concentrations in the tumor microe

• Gene expression of both GPR A and GPR in adipocytes

  2022-08-30

  

  Gene expression of both GPR109A and GPR81 in adipocytes has been linked to PPARγ activation [22]. Treatment with the thiazolidinedione (TZD) PPARγ agonist, rosiglitazone, increases GPR109A and GPR81 expression, and knockdown of PPARγ suppresses receptor expression in fully differentiated human mult

• nuciferine synthesis Taken together specific antibodies and

  2022-08-30

  

  Taken together, specific nuciferine synthesis and SR-SIM used in the study helped uniquely visualize the distribution of lymphocytes and macrophages with their molecular expression in human cochleae. Using SR-SIM, we verified that resident IBA1-positive macrophages are widely distributed in human c

• Hippo signaling is an emerging tumor suppressor pathway

  2022-08-29

  

  Hippo signaling is an emerging tumor suppressor pathway that plays key roles in normal physiology and tumorigenesis through the regulation of cellular proliferation and survival [4]. In humans, YAP is over-expressed as a result of genomic amplification of the 11q22 locus in a wide spectrum of human

• Introduction The West syndrome or epilepsy with epileptic sp

  2022-08-29

  

  Introduction The West syndrome or epilepsy with epileptic spasms (ES) is an epileptic encephalopathy in early infancy with probable seizure-related developmental regression. According to the United Kingdom Infantile Spams Study (UKISS), common causes of infantile spasms include hypoxic-ischemic enc

• br Introduction Anthocyanidins and anthocyanins glycosides o

  2022-08-29

  

  Introduction Anthocyanidins and anthocyanins (glycosides of anthocyanidins) are flavonoid phenolic compounds that are among the most common types of plant pigments [1]. They typically are responsible for the red, orange, blue, and violet colors in flowers, fruits, and vegetative tissues [1], [2]

• Acknowledgments br Introduction Type diabetes

  2022-08-29

  

  Acknowledgments Introduction Type 2 diabetes mellitus (T2DM) is caused by relative insulin deficiency or insulin resistance in peripheral tissues. The clinical management of T2DM is achieved by controlling blood glucose levels. Current therapies available for treatment of T2DM include biguanides

• Most excitingly we found the

  2022-08-29

  

  Most excitingly, we found the increased δ-cells hold the ability to trans-differentiate into β-cells in T1D mice. It has been shown that after near-total β-cell loss, juvenile mice display δ-to-β-cell conversion to recover diabetes, involving de-differentiation, proliferation and re-expression of is

• A pooled overall survival analysis at year

  2022-08-29

  

  A pooled overall survival analysis at 1year showed no difference in survival between the two study arms, although these studies were not designed or powered to demonstrate a survival benefit. Among the 979 total patients in both ROMANA 1 and 2, about 55% continued on to the ROMANA 3 trial. That tria

15135 records 344/1009 page Previous Next First page 上5页 341342343344345 下5页 Last page